Major urinary protein and immunoglobulin allotypes of recombinant inbred mouse strains
نویسندگان
چکیده
منابع مشابه
Immunoglobulin allotypes of the mouse.
morethanoneclassofheavychainflodd, 1963)couldonlyberationalized if these markers were present in the variable region. This has been the subject of muchcontroversy, as the presence of a genetic marker is indicative that the gene bearing it is present as only a single entity in the germ line, and hence an argument for somatic mutation as the mode of generation of antibody diversity. Sequence stud...
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We analyzed the susceptibility of 10 AKXD recombinant inbred (RI) mouse strains to lymphomas. These strains were derived from crosses of AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 10 strains analyzed, nine showed a high incidence of lymphoma development. As with the other 13 AKXD strains analyzed previously (M. L. Mucenski, B. A. Taylor, N. A. Jenkins,...
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A method was developed to quantitate the daily excretion of the three major urinary proteins (mups) to test which parameters of the mup phenotype are controlled by the the Mup-a gene. Electrophoretic separation of the mup proteins, followed by staining and spectrophotometric scanning was used to characterize the phenotypes of various inbred strains. The mup phenotype of a strain proved to have ...
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We have mapped the multiple (15-25) genes coding for the hormonally regulated major urinary proteins (MUPs) of the mouse by using a cloned cDNA probe. By Southern blot analysis of DNA from Chinese hamster-mouse somatic cell hybrids, all of the MUP genes were found to be on chromosome 4. Different inbred mouse strains showed DNA polymorphism in their MUP Southern hybridization pattern. Analysis ...
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Inbreeding of mice was begun in 1948 in our labora tories in response to the request of Dr. Franz Bielschow sky, who recognized the need for genetically and nutri tionally uniform animals for cancer research. The resulting strains of inbred NZ mice proved useful for research in immunology, biochemistry, and other fields, and they have been widely distributed. We often have inquiries from invest...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1973
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300013112